White Paper: Common Orthopedic Issues in Veterinary Medicine Introduction Orthopedic disorders are among the most prevalent health concerns in veterinary medicine, affecting companion animals, equine patients, and livestock. These conditions range from congenital deformities to acquired injuries and degenerative diseases, significantly impacting an animal’s mobility and quality of life. This white paper explores the most common orthopedic issues seen in veterinary practice, their causes, diagnostic approaches, and treatment options. 1. Fractures Causes and Risk Factors: Fractures occur due to trauma (e.g., vehicle accidents, falls) or underlying bone weaknesses such as metabolic bone disease or neoplasia. Types of Fractures: Diagnosis and Treatment: 2. Osteoarthritis (Degenerative Joint Disease) Causes and Risk Factors: Osteoarthritis (OA) is a progressive, degenerative disease resulting from joint wear and tear, trauma, or developmental abnormalities. Large breeds, overweight animals, and aging patients are at higher risk. Symptoms: Diagnosis and Treatment: 3. Hip Dysplasia Causes and Risk Factors: A genetic condition primarily affecting large dog breeds, hip dysplasia results from improper hip joint development, leading to instability and eventual arthritis. Symptoms: Diagnosis and Treatment: 4. Cruciate Ligament Rupture (ACL Injury) Causes and Risk Factors: Rupture of the cranial cruciate ligament (CCL) in dogs is a common cause of hind limb lameness, often resulting from obesity, genetic predisposition, or high-impact activities. Symptoms: Diagnosis and Treatment: 5. Luxating Patella Causes and Risk Factors: A common orthopedic issue in small dog breeds, patellar luxation occurs when the kneecap shifts out of its normal position due to congenital malformations or trauma. Symptoms: Diagnosis and Treatment: 6. Elbow and Shoulder Dysplasia Causes and Risk Factors: Developmental abnormalities in the elbow and shoulder joints, often hereditary, lead to joint instability and degeneration. Symptoms: Diagnosis and Treatment: 7. Intervertebral Disc Disease (IVDD) Causes and Risk Factors: IVDD occurs when spinal discs degenerate or herniate, compressing the spinal cord. It is common in chondrodystrophic breeds (e.g., Dachshunds, French Bulldogs). Symptoms: Diagnosis and Treatment: Conclusion Orthopedic conditions in veterinary medicine can significantly impact an animal’s quality of life. Early diagnosis and appropriate intervention are crucial to successful management. Advances in diagnostic imaging, surgical techniques, and biomaterials continue to improve outcomes in veterinary orthopedics. By understanding these common orthopedic issues, veterinarians can offer more effective, personalized treatment plans to enhance mobility and overall well-being in their patients. #VeterinaryOrthopedics #AnimalHealth #Boneadhesive #FractureRepair #JointCare #Osteoarthritis #VeterinarySurgery

The PBC Biomed Team are delighted to celebrate the success of another exceptional #ESTROT event following our time in Leeds last week. Our ‘Strengthening The Bond’ workshop on our #breakthrough bio-adhesive, OsStic®, attracted great interest and discussion, featuring a futuristic look at Bone Healing led by Prof. Thomas A. (Toney) Russell MD, including an interactive hands-on demonstration. As we begin the European roll-out of our ‘Strengthening the Bond’ educational platform, keynote presentations were delivered by Dr. Gerard Insley, Prof. Thomas A. (Toney) Russell MD. and researcher Srishti Agarwal on our developing technology. A sincere thank you to Prof. Peter Giannoudis for hosting and to the ESTROT organisers for all of their support — we’re already looking forward to ESTROT 2026! #ESTROT2025 #PBCBiomed #acceleratingmedicalinnovation #tissueregeneration #orthopaedics #traumatology

Kicking Off a New Partnership with Colorado State University’s Translational Medicine Institute Chief Medical Officer Dr Russell, R&D Director Paul Dorrell, R&D Engineer Antzela Tzagiollari are just back from a successful trip to the C. Wayne Mcilwraith Translational Medicine Institute in Colorado. Colorado State University’s Translational Medicine Institute is a state-of-the-art research hub which brings scholars, creators, and entrepreneurs together to work in a collaborative space where innovation thrives. The Institute’s goal is to discover and deliver solutions that utilize the body’s healing capacity and improve the lives of animals and the humans who care for them. This goal aligns perfectly with our mission to enhance patient well-being through the development of innovative new medical devices. We are delighted to be kicking off our partnership with this group! #biomimeticinnovations #acceleratingmedicalinnovation #researchanddevelopment

Strengthening Partnerships: Mochida Pharmaceuticals Visits Shannon HQ to discuss 2025 Collaborative Projects The Mochida Pharmaceuticals leadership, quality and regulatory teams visited our headquarters in Shannon, Ireland this month, to discuss collaborative development projects for 2025 and beyond. We are pleased to share that the future is bright, with projects planned for trauma, tendon & ligament, as well as cavernous nerve. Pictured below is our Managing Partner, Paul Burke and Chief Science Officer, Gerard Insley presenting Hitoshi Mizuno, Head of Biomaterials business Division at Mochida Pharmaceuticals Ltd, with a plaque to mark the successful launch of ReFeel Nerve Repair Solution ‘Le Cheile’. #mochidapharamceuticals #ReFeelnerverepairsolution #acceleratingmedicalinnovation #partners

This year our team will continue to work with Mochida Pharmaceutical Ltd. to explore further indications for alginate-based technologies, with projects focused on #tendon protection, #cavernous nerve repair and #cartilage treatment on the horizon. The product pipeline is exciting and our vision is clear – to develop #innovative medical technologies to enhance the wellbeing of patients globally. Pictured are Hitoshi Mizuno – Executive Managing Officer, Head of Biomaterials Business Division at Mochida Pharmaceutical; Gerard Insley – Chief Science Officer at PBC Biomed; Pierse Danaher -Finance Director at PBC Biomed; and Akihisa Iwabuchi – Associate Manager, Medical Device Quality Management and Regulatory Affairs at Mochida Pharmaceutical Ltd, on a recent trip to the Mochida Headquarters in Tokyo, Japan. #partnership #productpipeline #acceleratingmedicalinnovation #alginate

The PBC Biovet Operations Team has reached a significant milestone with the preparation and release of our very first OssiVet® order! OssiVet®, our innovative veterinary bioadhesive bone substitute, is designed to support advanced orthopedic care for companion animals, combining safety, efficacy, and ease of use. This landmark achievement is a testament to our team’s hard work, dedication, and commitment to delivering innovative solutions for veterinary orthopedic Application/ Fixation. 🔹 State-of-the-art preparation: Our team ensures the highest quality standards throughout the development lifecycle. 🔹 Seamless execution: From production to distribution, every step reflects our passion for excellence. 🔹 Onward to veterinarians: OssiVet® is now on its way to revolutionize bone surgeries in veterinary practices. We are proud to contribute to advancing veterinary care and look forward to hearing success stories from veterinarians using OssiVet® in their practices. #VeterinaryInnovation #PBCBiovet #OssiVet #Orthopedicsurgery

A special moment for our operations and manufacturing team last week, as they prepared the first commercial shipment of ReFeel Nerve Repair Solution for dispatch. After four years of manufacturing process setup, testing and small-scale production for pre-clinical studies, the first batch is now on its way to the US to be used in patients for the first time. Congratulations to this team and to our partners Mochida Pharmaceutical Co. Ltd., on all they have accomplished so far. Together, we have successfully developed and launched a technology that is truly #innovative and will enhance the well-being of patients. #commerciallaunch #acceleratingmedicalinnovation #pbcbiomed #ReFeelnerverepairsolution

We are excited to announce the release of new publication: ‘Alginate Use in Orthopedics and Peripheral Nerve Repair: A Systematic Review’; which is now live on the Cureus website. The aim of the paper is to examine alginate’s use in orthopaedic indications, as well as look at future applications of alginate for peripheral nerve repair. This publication was written by Dr Joshua Hustedt who based out of Banner Health, in Phoenix AZ. Dr. Joshua Hustedt, MD/MHS is a double board-certified, fellowship trained, hand, upper extremity, and peripheral nerve surgeon. Dr Hustedt has worked as part of the ReFeel development team with our partner company and legal manufacturer Mochida Pharmaceutical Ltd. Full publication can be accessed below – congratulations to Dr Hustedt on its release! https://www.cureus.com/articles/302391-alginate-use-in-orthopedics-and-peripheral-nerve-repair-a-systematic-review #ReFeelnerverepairsolution #peripheralnerverepair #nerverepair #alginate #orthopaedics #acceleratingmedicalinnovation

Curious to know how biomimetic technologies can support you in veterinary practice ? Meet with us at the London Vet Show on November 14-15, 2024, at ExCeL London, England. 📍 Booth S06 will feature our latest innovations in veterinary care, including: – Copperhawk , a Natural animal First Aid. – OssiVet™, a breakthrough bio adhesive designed to enhance surgical outcomes. We invite veterinary professionals and industry experts to visit us and learn more about how our products are driving innovation in animal health. 🗓️ Dates: November 14-15, 2024 📍 Booth: S06, ExCeL London We look forward to engaging with you at this important industry event. #LondonVetShow #Veterinary #BioMed #BioVet #Copperhawk #AnimalHealth #VetInnovation

PBC Biomed Inc welcomed the Mochida team to their Epicenter office in Memphis last week, ahead of the ReFeel Nerve Repair Solution launch.